This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not give yourself the injection unless you have received training from your healthcare provider. Aarp health insurance plans pdf download medicare replacement pdf download medicare benefits pdf download medicare part b pdf download how much does aranesp cost. As a substitute for red blood cell rbc transfusions in patients who require immediate correction of anemia. Aranesp darbepoetin alfa rationale for inclusion in.
Highlights of prescribing information these highlights do. Aranesp is an erythropoiesisstimulating agent esa indicated for the treatment of anemia due to. Aranesp is indicated for the treatment of anemia associated with chronic renal failure, including patients on dialysis and patients not on dialysis, and for the treatment of anemia in patients with nonmyeloid malignancies where anemia is due to the effect of. Highlights of prescribing information these highlights do not include all the information needed to use aranesp safely and effectively. If you are prescribed a partial dose of aranesp, start with step g below. Aranesp darbepoetin alfa is indicated for the treatment of anemia due to chronic kidney. Choose from a variety of file types multiple pdf files, microsoft word documents, microsoft excel spreadsheets, microsoft powerpoint.
Aranesp is a medicine used to treat anaemia low red blood cell counts that is causing symptoms. Aranesp 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 300, 500 micrograms solution for injection in prefilled pen aranesp in a prefilled pen is only for subcutaneous administration. Do not use aranesp if the liquid in the vial looks discolored or cloudy, or if the liquid has lumps, flakes, or particles. Aranesp fertigspritze gebrauchsinformation medikamio. Aranesp 10 mikrogramm injektionslosung in einer fertigspritze. Do not use a vial of aranesp if the color cap on the top of the vial has been removed or is missing. Aranesp is a 165amino acid protein that differs from recombinant human erythropoietin in containing 5 nlinked oligosaccharide chains, whereas recombinant human erythropoietin contains 3 chains. Aranesp is not indicated for use as a substitute for red blood cell transfusions in. The iv route of administration is recommended for adult patients on hemodialysis. Do not remove the grey needle shield from the prefilled pen until you are ready to inject. Get emergency medical help if you have signs of an allergic reaction hives, wheezing, difficult breathing, severe dizziness or fainting, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling darbepoetin alfa can increase your risk of lifethreatening heart or.
Aranesp darbepoetin alfa dose, indications, adverse. Ask your doctor if you have any questions about why aranesp has been prescribed for you. Before using darbepoetin alfa, tell your doctor or pharmacist if you are allergic to it. Anemia secondary to myelodysplastic syndrome mds endogenous serum erythropoietin level of. Aranesp works by stimulating your bone marrow to make red blood cells. Aranesp darbepoetin alfa is an erythropoiesisstimulating agent, or esa, used to treat anemia a lack of red blood cells in the body in people with longterm serious kidney disease chronic renal failure and people receiving chemotherapy for some types of cancer. Amgenkyowa hakko kirin is a recombinant human erythropoietin product administered by intravenous or subcutaneous injection, and is indicated for the treatment of anemia in chronic kidney disease and chemotherapyinduced anemia. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Compare aranesp vs procrit comprehensive analysis by. Use winrar or similar software to merge part 1 and 2. Chronic kidney disease ckd in patients on dialysis and patients not on. Aranesp darbepoetin alfa aranesp fep clinical rationale rationale for inclusion in pa program background aranesp is an erythropoiesis stimulating agent esa that binds to progenitor stem cells and stimulates the production and differentiation of red blood cells rbc. Find out what health conditions may be a health risk when taken with aranesp in albumin injection. Product information aranesp darbepoetin alfa cds v28 19112019 page 6 of 32 patients with nonmyeloid malignancies receiving chemotherapy treatment should not be commenced unless haemoglobin falls below 100110 gl.
Aranesp is indicated for the treatment of anemia due to chronic kidney disease ckd, including patients on dialysis and patients not on dialysis. These events included myocardial infarction, stroke, and congestive heart failure. Aranesp increases the risk for seizures in patients with ckd 5. Aranesp is a medicine that can be prescribed to treat anemia due to chronic kidney failure or chemotherapy. After two to six weeks of treatment, your red blood cell counts may increase. Aranesp 500 mikrogramm injektionslosung in einer fertigspritze.
Count slowly to 15 you may hear a second click as the red button pops back up. Serious heart problems, such as heart attack or heart failure, and stroke. High blood pressure that is not controlled by other medicines. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for aranesp darbepoetin alfa. No trial has identified a hemoglobin target level, aranesp dose, or dosing strategy that does not increase these risks 2. The manufacturer of the drug also filed an application with the fda on september 18, 2001, to receive an indication for treatment of anemia in patients with cancer robert hunter, amgen medical.
In controlled trials, patients with chronic kidney disease such as renal impairment or renal failure experienced greater risks for mortality, serious adverse cardiovascular reactions, and stroke when administered erythropoiesisstimulating agents esas such as darbepoetin alfa to target a hemoglobin concentration greater than 11 gdl. For a full dose, go directly to step 3, and choose between the subcutaneous or port injection based on your healthcare providers instructions. This product may contain inactive ingredients such as polysorbate, latex, which can cause allergic reactions or other problems. Chronic kidney disease ckd in patients on dialysis and. Use these instructions for use if you or your caregiver has been trained to give aranesp injections at home. If you are prescribed a full dose of aranesp, you will inject all of the medicine from your prefilled syringe.
Following iv administration to these patients, aranesp serum. Side effects of aranesp darbepoetin alfa, warnings, uses. Pdf zusammenfugen online pdf dateien zusammenfugen. Your doctor has given you aranesp to treat your anaemia. Medication is covered on plan if determined not to be covered under medicare part a or medicare part b and when being prescribed. Highlights of prescribing information these highlights do not include all the information needed to use aranespsafely and effectively. Usmle boards and beyond hematology part 1 jason ryan. Aranesp will help your bone marrow to produce more red blood cells, like your natural erythropoietin. Rotate the injection sites to avoid discomfort at the site of injection. The main measure of effectiveness was the reduction in number of patients who needed a blood transfusion. Sep 14, 2001 following iv administration to adult crf patients, aranesp serum. The aranesp vial has a color cap on the top of the vial. Aranesp is a recombinant erythropoietic protein produced by special mammalian cells.
For all people who take aranesp, including people with cancer or chronic kidney disease. Aranesp in albumin injection interactions with other. Aranesp solution for injection in prefilled syringe. It is recommended that the dose of aranesp be decreased if the hemoglobin increase darbepoetin alfa fda. Aranesp 10 micrograms solution for injection in prefilled syringe aranesp 15 micrograms solution for injection in prefilled syringe aranesp 20 micrograms solution for injection in prefilled syringe aranesp 30 micrograms solution for injection in prefilled syringe. Aranesp is a manmade form of the protein human erythropoietin eerithrowpoehtin. The aranesp liquid in the vial is clear and colorless. Do not leave the prefilled pen exposed to direct sunlight.
Hgb is less than or equal to 12gdl or hct is less than or equal to 36%. Instructions for use aranesp airuhnesp darbepoetin alfa. Aranesp 300 mikrogramm injektionslosung in einer fertigspritze. Instructions for use aranesp airuhnesp darbepoetin. Dieses kostenlose tool erlaubt es mehrere pdfs oder bilddateien miteinander zu einem pdfdokument zu verbinden. How to combine files into a pdf adobe acrobat dc tutorials. These medications may interact and cause very harmful effects. Aranesp has also been compared with placebo a dummy treatment in two studies involving 669 patients receiving chemotherapy for cancer such as lung cancer, myeloma or lymphoma. If severe anemia and low reticulocyte count develop during aranesp treatment, withhold aranesp and evaluate for prca 5. This emedtv resource describes the effects of aranesp, explains how and when to take the drug, and lists possible side effects that may occur.
Before you use it when you must not use aranesp do not use aranesp if you have. Aranesp is used to treat anemia caused by chemotherapy or chronic kidney. Automatic needle guard ang user training guide aranesp provides safe and convenient administration options the ang prefilled syringe helps simplify administration and protects against unintentional needlesticks. Name of drug strength ndc price effective february 1, 2017 feb 1, 2017 aranesp. When fewer red blood cells are produced, you can develop a condition called anemia. Increase monitoring of these patients for changes in seizure frequency or premonitory symptoms 5. Initiate aranesp for patients on cancer chemotherapy only if the hb is webmd provides common contraindications for aranesp in albumin injection.
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