Instructions for use aranesp airuhnesp darbepoetin. When it is due to chronic kidney failure renal failure when it occurs due to chemotherapy in people with cancer. Before you use it when you must not use aranesp do not use aranesp if you have. Aarp health insurance plans pdf download medicare replacement pdf download medicare benefits pdf download medicare part b pdf download how much does aranesp cost. The aranesp liquid in the vial is clear and colorless. This product may contain inactive ingredients such as polysorbate, latex, which can cause allergic reactions or other problems. Your doctor has given you aranesp to treat your anaemia. Aranesp has also been compared with placebo a dummy treatment in two studies involving 669 patients receiving chemotherapy for cancer such as lung cancer, myeloma or lymphoma. For a full dose, go directly to step 3, and choose between the subcutaneous or port injection based on your healthcare providers instructions. In controlled trials, patients with chronic kidney disease such as renal impairment or renal failure experienced greater risks for mortality, serious adverse cardiovascular reactions, and stroke when administered erythropoiesisstimulating agents esas such as darbepoetin alfa to target a hemoglobin concentration greater than 11 gdl. Aranesp darbepoetin alfa rationale for inclusion in.
Aranesp is a medicine that can be prescribed to treat anemia due to chronic kidney failure or chemotherapy. The food and drug administration fda approved darbepoetin alfa aranesp for treatment of anemia as sociated with chronic renal failure crf in patients on dialysis and patients not on dialysis. Product information aranesp darbepoetin alfa cds v28 19112019 page 6 of 32 patients with nonmyeloid malignancies receiving chemotherapy treatment should not be commenced unless haemoglobin falls below 100110 gl. Aranesp is indicated for the treatment of anemia associated with chronic renal failure, including patients on dialysis and patients not on dialysis, and for the treatment of anemia in patients with nonmyeloid malignancies where anemia is due to the effect of. Usmle boards and beyond hematology part 1 jason ryan. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Rotate the injection sites to avoid discomfort at the site of injection. Dieses kostenlose tool erlaubt es mehrere pdfs oder bilddateien miteinander zu einem pdfdokument zu verbinden. Ask your doctor if you have any questions about why aranesp has been prescribed for you. After two to six weeks of treatment, your red blood cell counts may increase. Aranesp will help your bone marrow to produce more red blood cells, like your natural erythropoietin. Anemia secondary to myelodysplastic syndrome mds endogenous serum erythropoietin level of.
If severe anemia and low reticulocyte count develop during aranesp treatment, withhold aranesp and evaluate for prca 5. Aranesp darbepoetin alfa is an erythropoiesisstimulating protein that is produced in chinese hamster ovary cho cells by recombinant dna technology. Aranesp is a recombinant erythropoietic protein produced by special mammalian cells. Use winrar or similar software to merge part 1 and 2. Name of drug strength ndc price effective february 1, 2017 feb 1, 2017 aranesp. Pdf zusammenfugen online pdf dateien zusammenfugen. Get emergency medical help if you have signs of an allergic reaction hives, wheezing, difficult breathing, severe dizziness or fainting, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling darbepoetin alfa can increase your risk of lifethreatening heart or.
The aranesp vial has a color cap on the top of the vial. Aranesp is used to treat anemia caused by chemotherapy or chronic kidney. Automatic needle guard ang user training guide aranesp provides safe and convenient administration options the ang prefilled syringe helps simplify administration and protects against unintentional needlesticks. Do not use aranesp if the liquid in the vial looks discolored or cloudy, or if the liquid has lumps, flakes, or particles. These medications may interact and cause very harmful effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Chronic kidney disease ckd in patients on dialysis and. Hgb is less than or equal to 12gdl or hct is less than or equal to 36%. Aranesp 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 300, 500 micrograms solution for injection in prefilled pen aranesp in a prefilled pen is only for subcutaneous administration. Following iv administration to these patients, aranesp serum.
Increase monitoring of these patients for changes in seizure frequency or premonitory symptoms 5. Aranesp in albumin injection interactions with other. When fewer red blood cells are produced, you can develop a condition called anemia. Do not remove the grey needle shield from the prefilled pen until you are ready to inject. Sep 14, 2001 following iv administration to adult crf patients, aranesp serum. Aranesp 300 mikrogramm injektionslosung in einer fertigspritze.
How to combine files into a pdf adobe acrobat dc tutorials. Instructions for use aranesp airuhnesp darbepoetin alfa. Find out what health conditions may be a health risk when taken with aranesp in albumin injection. Before using darbepoetin alfa, tell your doctor or pharmacist if you are allergic to it.
It is recommended that the dose of aranesp be decreased if the hemoglobin increase darbepoetin alfa fda. Serious heart problems, such as heart attack or heart failure, and stroke. Aranesp 10 micrograms solution for injection in prefilled syringe aranesp 15 micrograms solution for injection in prefilled syringe aranesp 20 micrograms solution for injection in prefilled syringe aranesp 30 micrograms solution for injection in prefilled syringe. High blood pressure that is not controlled by other medicines. Amgenkyowa hakko kirin is a recombinant human erythropoietin product administered by intravenous or subcutaneous injection, and is indicated for the treatment of anemia in chronic kidney disease and chemotherapyinduced anemia. Aranesp is a medicine used to treat anaemia low red blood cell counts that is causing symptoms. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for aranesp darbepoetin alfa. Medication is covered on plan if determined not to be covered under medicare part a or medicare part b and when being prescribed. Side effects of aranesp darbepoetin alfa, warnings, uses. Count slowly to 15 you may hear a second click as the red button pops back up. Aranesp 10 mikrogramm injektionslosung in einer fertigspritze. As a substitute for red blood cell rbc transfusions in patients who require immediate correction of anemia. Highlights of prescribing information these highlights do not include all the information needed to use aranesp safely and effectively. Aranesp fertigspritze gebrauchsinformation medikamio.
Aranesp darbepoetin alfa aranesp fep clinical rationale rationale for inclusion in pa program background aranesp is an erythropoiesis stimulating agent esa that binds to progenitor stem cells and stimulates the production and differentiation of red blood cells rbc. These events included myocardial infarction, stroke, and congestive heart failure. For all people who take aranesp, including people with cancer or chronic kidney disease. Aranesp increases the risk for seizures in patients with ckd 5. Initiate aranesp for patients on cancer chemotherapy only if the hb is webmd provides common contraindications for aranesp in albumin injection. Highlights of prescribing information these highlights do. Chronic kidney disease ckd in patients on dialysis and patients not on. Use these instructions for use if you or your caregiver has been trained to give aranesp injections at home. Aranesp is a manmade form of the protein human erythropoietin eerithrowpoehtin. Aranesp works by stimulating your bone marrow to make red blood cells. Aranesp darbepoetin alfa dose, indications, adverse. Highlights of prescribing information these highlights do not include all the information needed to use aranespsafely and effectively.
If you are prescribed a full dose of aranesp, you will inject all of the medicine from your prefilled syringe. Do not give yourself the injection unless you have received training from your healthcare provider. Aranesp is an erythropoiesisstimulating agent esa indicated for the treatment of anemia due to. The main measure of effectiveness was the reduction in number of patients who needed a blood transfusion. Aranesp is a 165amino acid protein that differs from recombinant human erythropoietin in containing 5 nlinked oligosaccharide chains, whereas recombinant human erythropoietin contains 3 chains. If you are prescribed a partial dose of aranesp, start with step g below. The iv route of administration is recommended for adult patients on hemodialysis. This emedtv resource describes the effects of aranesp, explains how and when to take the drug, and lists possible side effects that may occur.
The manufacturer of the drug also filed an application with the fda on september 18, 2001, to receive an indication for treatment of anemia in patients with cancer robert hunter, amgen medical. Aranesp 500 mikrogramm injektionslosung in einer fertigspritze. Do not leave the prefilled pen exposed to direct sunlight. Aranesp is not indicated for use as a substitute for red blood cell transfusions in. Choose from a variety of file types multiple pdf files, microsoft word documents, microsoft excel spreadsheets, microsoft powerpoint. Aranesp solution for injection in prefilled syringe. Compare aranesp vs procrit comprehensive analysis by.
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